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January 14, 2004

Treatment of Sarin Exposure—Reply

Author Affiliations

Letters Section Editor: Stephen J. Lurie, MD, PhD, Senior Editor.

JAMA. 2004;291(2):181. doi:10.1001/jama.291.2.182-b

In Reply: I agree with Dr Krivoy and colleagues that a search is underway for an alternative or adjunct to diazepam as an antiseizure treatment. Shih and McDonough1 have shown that its effectiveness is decreased when administered 40 minutes after seizure onset. However, in another study McDonough et al2 also found that diazepam was the most potent compound when administered 40 minutes after seizure onset compared with 8 anticholinergic drugs, including benactyzine.

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