[Skip to Content]
[Skip to Content Landing]
February 11, 2004

Regulation of Synovial Adipocytokines

Author Affiliations

Letters Section Editor: Stephen J. Lurie, MD, PhD, Senior Editor.

JAMA. 2004;291(6):694-695. doi:10.1001/jama.291.6.694-c

To the Editor: In their Research Letter, Dr Schäffler and colleagues1 found adiponectin and resistin in the synovial fluid of patients with rheumatoid arthritis (RA) and, to a lesser degree, in those with osteoarthritis (OA). The authors suggested that these 2 adipocytokines might play a role in chronic inflammatory joint disease. They also found a positive association between adiponectin and C-reactive protein (CRP) in patients with OA, which is at variance with the previously reported inverse correlation between plasma adiponectin and markers of inflammation such as CRP, tumor necrosis factor α (TNF-α), and interleukin 6.2,3 Other studies have suggested that adiponectin has an anti-inflammatory rather than a proinflammatory effect.4