Letters Section Editor: Stephen J. Lurie,
MD, PhD, Senior Editor.
To the Editor: In their Research Letter, Dr
Schäffler and colleagues1 found adiponectin
and resistin in the synovial fluid of patients with rheumatoid arthritis (RA)
and, to a lesser degree, in those with osteoarthritis (OA). The authors suggested
that these 2 adipocytokines might play a role in chronic inflammatory joint
disease. They also found a positive association between adiponectin and C-reactive
protein (CRP) in patients with OA, which is at variance with the previously
reported inverse correlation between plasma adiponectin and markers of inflammation
such as CRP, tumor necrosis factor α (TNF-α), and interleukin
6.2,3 Other studies have
suggested that adiponectin has an anti-inflammatory rather than a proinflammatory
Stefan N, Häring H, Stumvoll M. Regulation of Synovial Adipocytokines. JAMA. 2004;291(6):694–695. doi:10.1001/jama.291.6.694-c
Customize your JAMA Network experience by selecting one or more topics from the list below.
Create a personal account or sign in to: