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Rabies is a rapidly progressive, incurable viral encephalitis that is,
with rare exception, transmitted by the bite of an infected mammal. On September
14, 2003, a previously healthy man aged 66 years who resided in Trinity County,
California, died from rabies approximately 6 weeks after being bitten by a
bat. This report summarizes the investigation by the Trinity and Shasta County
Health Departments and the California Department of Health Services (CDHS).
Persons should avoid direct contact with bats; however, if such contact occurs,
the exposed person should visit a health-care provider immediately, and the
exposure should be reported to local public health officials.
In September 2003, the patient was admitted to a hospital emergency
department (ED) for assessment of atypical chest pain. He had a 2-week history
of mild, nonspecific complaints (e.g., drowsiness, chronic headache, and malaise),
a 5-day history of progressive right arm pain and paresthesias, and a 1-day
history of right-hand weakness. The arm pain was severe enough to wake him
from sleep and progressively worsened. He also described a sharp pain radiating
bilaterally up the right arm to his axilla and left chest. The pain was relieved
by administering nitroglycerin in the ED. The patient reported being bitten
by a bat on the right index finger while in his bed approximately 5 weeks
before admission. He removed the bat from his home, and it flew away. The
patient washed the wound but did not seek rabies postexposure prophylaxis
(PEP) at that time. Because the patient reported to the ED at an early stage
of rabies infection, with predominantly local symptoms near the bite site,
rabies vaccine, rabies immune globulin, ribavirin, and interferon-alpha were
administered on the day of admission; a second dose of rabies vaccine was
administered 3 days later.
On admission, he was afebrile, alert, and oriented but had decreased
right upper extremity strength, decreased sensation to light touch, and slight
impairment in his ability to concentrate. His white blood cell (WBC) count
was elevated at 13,900 cells/µL (normal: 3,700-9,400 cells/µL).
All other laboratory values were within the normal range.
The patient had steady neurologic decline during the following week
with confusion and disorientation. He became febrile on the fourth hospital
day and was intubated for airway protection. Electromyography of his right
and left upper extremities indicated distal demyelinating polyneuropathy.
By the fifth hospital day, he had a right lung infiltrate, and his electroencephalogram
showed diffuse slowing. Two days later, he died. Four family members and two
of 40 health-care workers involved in the patient's treatment received rabies
PEP as a precautionary measure. The patient's wife received PEP because she
had been asleep in the same bed as the patient when the bat bit him and possibly
had been exposed to the same bat.
Antemortem specimens were sent to the Viral and Rickettsial Disease
Laboratory (VRDL) at CDHS and to CDC for evaluation. The specimens included
multiple saliva and serum samples, nuchal skin biopsy, urine, and spinal fluid.
Postmortem corneal impressions also were obtained. A nested, reverse transcription
polymerase chain reaction assay performed on saliva samples was positive for
evidence of rabies virus nucleic acid. Sequence analysis demonstrated 100%
homology with a rabies virus variant associated with the silver-haired bat
A Deckert, MD, Shasta County Public Health, Redding; C Glaser, MD, Viral
and Rickettsial Disease Laboratory; B Sun, DVM, Div of Communicable Disease
Control, California Dept of Health Svcs. Div of Viral and Rickettsial Diseases,
National Center for Infectious Diseases; L Demma, PhD, EIS Officer, CDC.
Although human rabies is rare in the United States, clinicians and public
health workers should suspect rabies when a history of possible bat contact
is known or when unexplained atypical progressive neuropathy or unusual febrile
encephalitis is observed. Persons coming in direct contact with bats should
seek consultation with their health-care providers immediately to receive
PEP, if appropriate.
Rabies is an acute, progressive, and fatal disease. The only documented
survivors received rabies prophylaxis before the onset of illness. However,
an aggressive approach to therapy might be attempted in patients who are in
an early stage of clinical disease.1 A combination
of therapies is suggested, including rabies vaccine, rabies immune globulin,
ribavirin, interferon-alpha, mono clonal antibodies, and ketamine. The patient
described in this report visited the ED at an early stage with a predominant
symptom of paraesthesia at the bite site. He was treated within approximately
24 hours of admission, albeit unsuccessfully, with the first four of these
This fatality follows two other recent bat-associated cases of human
rabies in California (in Glenn County in 2002 and in Amador County in 2000).2,3 However, these cases were associated
with a Mexican free-tailed bat (Tadarida brasiliensis)
rabies virus variant, and neither patient identified a definitive bat exposure.
During 1990-1998, of 22 bat-associated rabies infections, 16 (75%) were associated
with the virus variant found among silver-haired and eastern pipistrelle bats.4 Properties of these viruses might allow infection
and replication under broader conditions than those of other rabies virus
During 1990-2000, a total of 24 (75%) of 32 U.S. human rabies cases
were caused by bat-associated rabies virus variants. In 22 (92%) of these
cases, no documentation of a bite existed; however, this does not mean that
a typical bite exposure did not take place. Instead, such a history was not
uncovered during presentation or case investigation.
Human rabies is preventable with the proper and timely administration
of rabies PEP.6 However, if a patient does
not recognize the risk associated with an animal bite, PEP probably will not
be obtained. When a bat is found in living quarters and a strong possibility
exists that an exposure might have occurred, the animal should be submitted
to a local public health laboratory for diagnostic testing. However, if the
animal is not available for testing, PEP should be administered when there
is a strong probability of exposure.
No laboratory-confirmed cases of human-to-human transmission from patients
to health-care workers or family members have been documented. Delivery of
health care to a patient with rabies is not an indication for PEP unless a
bite has occurred or an exposure of mucous membranes or nonintact skin to
potentially infectious body fluids has occurred.6 Adherence
to standard safety precautions for health-care workers will minimize the risk
Public health professionals need to reemphasize effective measures to
reduce animal exposure and to keep pet and livestock vaccinations current.
Persons who are bitten by a potentially rabid animal should immediately (1)
disinfect and wash the wound, (2) capture the animal safely, (3) contact the
local health department, and (4) see a physician for evaluation about the
need for PEP.
This report is based on data contributed by E Osvold-Doppelhauer, Trinity
County Health Dept, Weaverville; C Lakmann, K Thomas, Shasta County Public
Health; H Birk, MD, KK Shwe, MD, S Menezes, MD, M O'Brien, MD, L Dayton, MD,
Mercy Medical Center, Redding; D Schnurr, PhD, S Honarmand, C Kohlmeier, Viral
and Rickettsial Disease Laboratory, Div of Communicable Disease Control, California
Dept of Health Svcs. L Orciari, MS, M Niezgoda, MS, Div of Viral and Rickettsial
Diseases, National Center for Infectious Diseases, CDC.
Human Death Associated with Bat Rabies—California, 2003. JAMA. 2004;291(7):816–817. doi:https://doi.org/10.1001/jama.291.7.816
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