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March 17, 2004

Whole-Body Imaging for Cancer Staging—Reply

Author Affiliations

Letters Section Editor: Stephen J. Lurie, MD, PhD, Senior Editor.

JAMA. 2004;291(11):1320. doi:10.1001/jama.291.11.1320-c

In Reply: We agree with Dr Osman that the brain is an important site of potential metastatic spread. The head was part of the imaging field of view in all patients, and data analysis included assessment of the brain and skull. Thus, metastases to the brain and skull contributed to the assessment of the M-stage by the 2 imaging procedures. While bone metastases (including metastases to the skull) were evaluated separately in addition to the overall M-stage, the number of patients with metastases to the brain was too small for separate data analysis.