Citing concerns that women were being put at an increased risk for stroke,
National Institutes of Health officials told participants in the estrogen-alone
study of the Women's Health Initiative (WHI) hormone therapy trial to stop
taking their pills. In addition, enough data had been compiled to conclude
that estrogen alone does not seem to affect heart disease, the study's key
The findings also indicated that estrogen alone appears to decrease
the risk of hip fracture. However, the risk of breast cancer during the study
period was not affected.
Hampton T. Estrogen Trial Halted. JAMA. 2004;291(12):1434. doi:10.1001/jama.291.12.1434-a
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