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March 24/31, 2004

Etiology of the Metabolic Syndrome

Author Affiliations

Letters Section Editor: Stephen J. Lurie, MD, PhD, Senior Editor.

JAMA. 2004;291(12):1443. doi:10.1001/jama.291.12.1443-b

To the Editor: In his Editorial about the metabolic syndrome, Dr Grundy1 offered several possible explanations for an apparent correlation between elevated C-reactive protein levels and the risk of developing hypertension, a relationship of questionable significance. This leads me to question whether the term "metabolic syndrome," a generic phrase for a rather specific group of physiologic impairments, makes sense. Perhaps it would be more precise to rename this "syndrome" the "insulin resistance/obesity complex?" Such a designation would have the advantage of properly designating the major aspects of the disturbances as outlined by Grundy, rather than inappropriately dignifying it with a phrase of vast content and no specificity.