Letters Section Editor: Stephen J. Lurie,
MD, PhD, Senior Editor.
In Reply: Dr Miller questions whether the term
"metabolic syndrome" is appropriate for the clustering of risk factors that
are commonly associated with obesity and insulin resistance. The metabolic
syndrome is a multidimensional risk factor consisting of 5 metabolic risk
factors, including atherogenic dyslipidemia, elevated blood pressure, glucose
intolerance, a prothrombotic state, and a proinflammatory state. The root
causes of the syndrome appear to be multiple and include obesity (especially
abdominal obesity), physical inactivity, insulin resistance, aging, and genetics.1-3
Grundy SM. Etiology of the Metabolic Syndrome—Reply. JAMA. 2004;291(12):1443. doi:10.1001/jama.291.12.1444-a
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