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March 24/31, 2004

Etiology of the Metabolic Syndrome—Reply

Author Affiliations

Letters Section Editor: Stephen J. Lurie, MD, PhD, Senior Editor.

JAMA. 2004;291(12):1443. doi:10.1001/jama.291.12.1444-a

In Reply: Dr Miller questions whether the term "metabolic syndrome" is appropriate for the clustering of risk factors that are commonly associated with obesity and insulin resistance. The metabolic syndrome is a multidimensional risk factor consisting of 5 metabolic risk factors, including atherogenic dyslipidemia, elevated blood pressure, glucose intolerance, a prothrombotic state, and a proinflammatory state. The root causes of the syndrome appear to be multiple and include obesity (especially abdominal obesity), physical inactivity, insulin resistance, aging, and genetics.1-3