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March 24/31, 2004

Synthetic Thyroxine vs Dessicated Thyroid

Author Affiliations

Letters Section Editor: Stephen J. Lurie, MD, PhD, Senior Editor.

JAMA. 2004;291(12):1445. doi:10.1001/jama.291.12.1445-a

To the Editor: Dr Clyde and colleagues1 concluded that treatment of primary hypothyroidism with combination levothyroxine plus liothyronine was not superior to levothyroxine alone in terms of body weight, serum lipid levels, hypothyroid symptoms, or cognitive performance. Although Clyde et al recommend that patients should be treated with synthetic thyroid on the basis of cost, natural desiccated thyroid is considerably less expensive. Thus, perhaps this would be the most rational treatment choice.