Letters Section Editor: Stephen J. Lurie,
MD, PhD, Senior Editor.
To the Editor: Dr Liu and colleagues1 reported that among patients receiving dialysis,
cholesterol levels and mortality were inversely associated among patients
with chronic inflammation but were positively associated in those without
inflammation. The authors concluded that inverse relationships between cholesterol
and mortality in previous studies of this population are due to the cholesterol-lowering
effect of malnutrition and systemic inflammation, rather than to a protective
effect of high cholesterol levels. However, there is considerable epidemiologic,
clinical, and laboratory evidence that high cholesterol levels protect against
infections, while low cholesterol levels predispose to infections.2
Ravnskov U. Inflammation, Cholesterol Levels, and Risk of Mortality Among Patients Receiving Dialysis. JAMA. 2004;291(15):1833–1834. doi:10.1001/jama.291.15.1833
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