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July 7, 2004

Sex Differences in Mortality After Coronary Artery Bypass Graft Surgery—Reply

JAMA. 2004;292(1):40-41. doi:10.1001/jama.292.1.41-a

In Reply: Dr Habib and colleagues suggest that the hazard ratios we reported do not take into account differences in demographics and comorbid conditions, and that we might have found different results had we applied propensity modeling.

As we pointed out in our article, we calculated risk-adjusted hazard ratios in our mortality analyses. This analysis accounted for a large number of variables associated with demographics, comorbid conditions, and disease-specific severity. We also conducted a propensity modeling analysis, although using an approach different from that used by Koch et al,1 as well as an analysis in which we stratified outcome comparisons by anatomical risk. Our conclusion that women have poorer outcomes than men, particularly early after revascularization procedures, was persistent across various analysis strategies.