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July 21, 2004

Frequency of Ejaculation and Risk of Prostate Cancer

Author Affiliations

Letters Section Editor: Stephen J. Lurie, MD, PhD, Senior Editor.

JAMA. 2004;292(3):329. doi:10.1001/jama.292.3.329-a

To the Editor: In their prospective study, Dr Leitzmann and colleagues1 replicated the findings of our case-control study2 in regard to a protective relationship between frequency of ejaculation and risk of prostate cancer. Although the study of Leitzmann et al avoids the potential for recall bias, for both their study and ours the accuracy of ejaculation assessment was likely to be affected by problems in recall of past practice, particularly of that in early adult life. We believe that the effect of such a bias would tend to be conservative and would have thus underestimated any real effect for ejaculation.

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