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July 28, 2004

Radiation Therapy and Risk of Cardiovascular Disease

Author Affiliations

Letters Section Editor: Robert M. Golub, MD, Senior Editor.

JAMA. 2004;292(4):433-434. doi:10.1001/jama.292.4.433-b

To the Editor: Dr Hull and colleagues1 found that radiation therapy was associated with an increased incidence of atherosclerotic events among patients with Hodgkin lymphoma. Many of these patients, however, were treated during a time when splenectomy was a common part of staging for Hodgkin disease. Splenectomy is a risk factor for myocardial infarction2-4 and other atherosclerotic events.3 I believe that the authors should have accounted for splenectomy status in their analysis.