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August 11, 2004

Effects of Estrogen-Only Treatment in Postmenopausal Women

Author Affiliations

Letters Section Editor: Robert M. Golub, MD, Senior Editor.

JAMA. 2004;292(6):683. doi:10.1001/jama.292.6.683-a

To the Editor: The Women's Health Initiative (WHI) investigators1 found that use of conjugated equine estrogen (CEE) was associated with a decreased risk of breast cancer among women with prior hysterectomy. However, the trial was discontinued early and I do not feel that this early termination was justified, given that the cumulative hazard ratio (HR) of 0.77 (95% confidence interval [CI], 0.59-1.01) narrowly missed statistical significance. It would have been important to study the effects of additional years of treatment, as knowledge of hormone-dependent cancers remains incomplete.