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August 11, 2004

Effects of Estrogen-Only Treatment in Postmenopausal Women—Reply

Author Affiliations

Letters Section Editor: Robert M. Golub, MD, Senior Editor.

JAMA. 2004;292(6):683. doi:10.1001/jama.292.6.685-c

In Reply: Regarding Dr Kuhl's concern about the early stopping of our trial, we regret that the WHI cannot provide more definitive data on the effects of CEE on breast cancer including longer-term use, or on potential benefits for CHD, since these questions provided the primary motivation for our trial. It remains possible that CEE may have reduced CHD rates in women aged 50 to 59 years at enrollment, but our data cannot resolve this issue. We disagree with Kuhl's concern about the relevance of our sample, however, as the women in WHI represent the very women for whom CHD primary prevention would be considered.