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Books, Journals, New Media
October 13, 2004

Diabetes, Cardiovascular Disease

JAMA. 2004;292(14):1754-1760. doi:10.1001/jama.292.14.1756-a

The editors of Diabetes and Cardiovascular Disease wished to bring together fundamental principles and recent findings on diabetes as related to cardiovascular biology in a way that would be “sufficiently concise to be clinically useful.” To achieve their goal they have sought the expertise of 49 contributors from leading medical centers around the world.

The book has two parts: “Vascular Biology” and “Clinical Topics.” “Vascular Biology” covers the molecular and cellular mechanisms that lead to microvascular and macrovascular complications in patients with diabetes. The first chapter is an excellent review of the contributions of hyperglycemia, insulin resistance, cytokines, and vasoactive hormones to the development of vascular disease. Specific chapters describe the roles of antioxidants, oxidative stress, inflammation, protein kinase C, aldose reductase, peroxisome proliferator-activator receptors, vascular stress, and genetic predisposition in diabetic vascular dysfunction. This part of the book probably would be more beneficial to clinicians involved in research because of the details provided on the cellular and molecular mechanisms of the vascular disease and diabetes. But, as a clinician involved in the care of patients with diabetes, I also found it a useful reference for increasing knowledge of this complex disease.

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