The editors of Diabetes and Cardiovascular Disease wished to bring together fundamental principles and recent findings
on diabetes as related to cardiovascular biology in a way that would be “sufficiently
concise to be clinically useful.” To achieve their goal they have sought
the expertise of 49 contributors from leading medical centers around the world.
The book has two parts: “Vascular Biology” and “Clinical
Topics.” “Vascular Biology” covers the molecular and cellular
mechanisms that lead to microvascular and macrovascular complications in patients
with diabetes. The first chapter is an excellent review of the contributions
of hyperglycemia, insulin resistance, cytokines, and vasoactive hormones to
the development of vascular disease. Specific chapters describe the roles
of antioxidants, oxidative stress, inflammation, protein kinase C, aldose
reductase, peroxisome proliferator-activator receptors, vascular stress, and
genetic predisposition in diabetic vascular dysfunction. This part of the
book probably would be more beneficial to clinicians involved in research
because of the details provided on the cellular and molecular mechanisms of
the vascular disease and diabetes. But, as a clinician involved in the care
of patients with diabetes, I also found it a useful reference for increasing
knowledge of this complex disease.
Vega-Miranda J. Diabetes, Cardiovascular Disease. JAMA. 2004;292(14):1754–1760. doi:10.1001/jama.292.14.1756-a
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