Letters Section Editor: Robert M. Golub,
MD, Senior Editor.
In Reply: Although we do not have information
about oral health for the participants in the Rotterdam Study, we do have
extensive information on osteoporosis and bone mineral density. The association
reported by Dr Taguchi and colleagues between ESR1 polymorphisms
and postmenopausal tooth loss in postmenopausal women is in line with an association
we found in men and women between these polymorphisms and osteoporosis.1 The same haplotype found to be associated with risk
of MI in postmenopausal women2 was also associated
with lumbar spine bone mineral density (BMD) and vertebral fracture risk in
these same women. Taguchi suggests that the association we found between ESR1 polymorphisms and ischemic heart disease may not be
a causal relationship but rather an indirect result of the associations between ESR1 polymorphisms and tooth loss, and between tooth loss
and risk of MI.
Schuit SCE, Uitterlinden AG, Pols HAP. Estrogen Receptor α Polymorphisms and the Risk of Myocardial Infarction—Reply. JAMA. 2004;292(14):1683–1684. doi:10.1001/jama.292.14.1683-b