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October 27, 2004

Tenofovir, Equivalence, and Noninferiority

Author Affiliations

Letters Section Editor: Robert M. Golub, MD, Senior Editor.

JAMA. 2004;292(16):1951-1952. doi:10.1001/jama.292.16.1951-a

To the Editor: Dr Gallant and colleagues1 compared the proportion of patients with HIV RNA levels less than 400 copies/mL at week 48 in antiretroviral-naive patients who randomly received either tenofovir or stavudine, in combination with efavirenz and lamivudine. The authors stated in their methods that “the study was designed as a noninferiority trial (ie, equivalence).” However, noninferiority and equivalence hypotheses are not identical.