In Reply: In response to Dr Atkins’ questions,
the log-rank P value of.04 was 2-sided and is the
metric most frequently used when there is no a priori assumption made about
early vs late differences, as was the case in our study at the time of its
inception. This P value compares the entire distribution
of both survival curves and not only the 5-year time point. There were no
significant differences in the distribution of the known prognostic factors
including age, PSA level, Gleason score, and clinical tumor category between
the 2 treatment groups. Finally, the proportional hazard assumptions for the
multivariable Cox models1 were tested and met.
D’Amico AV, Loffredo M, Manola J, DellaCroce A, Renshaw AA, Kantoff PW. Androgen Suppression Plus Radiation Therapy for Prostate Cancer—Reply. JAMA. 2004;292(17):2084–2085. doi:https://doi.org/10.1001/jama.292.17.2085-a
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