During the past 3 decades, major advances in maternal-fetal medicine,
neonatology, and translational developmental biology have resulted in survival
rates greater than 90% among the approximately 50 000 infants born annually
with birth weights between 1000 g (2.2 lb) and 1500 g (3.5 lb).1 In
addition, combinations of maternal and neonatal transport to specialized hospitals,
use of prenatal maternal corticosteroids, and enhanced collaboration between
obstetricians and neonatologists have resulted in survival rates greater than
70% for the approximately 10 000 infants born annually with birth weights
between 500 and 999 g.2-5 While
there has been success in improving survival among low-birth-weight infants,
preventing the adverse neurodevelopmental outcomes of extremely low-birth-weight
(ELBW) infants (weighing 401-1000 g at birth) remains a major challenge.
Msall ME. Developmental Vulnerability and Resilience in Extremely Preterm Infants. JAMA. 2004;292(19):2399–2401. doi:10.1001/jama.292.19.2399
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