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November 17, 2004

Proteomic Profiling and Intra-amniotic Infection—Reply

JAMA. 2004;292(19):2339-2340. doi:10.1001/jama.292.19.2338-b

In Reply: In response to Dr Buhimschi and colleagues, we would like to clarify several points. As we noted in the article, our SELDI-TOF proteomic profiling was a low-resolution approach to distinguish patients with and without IAI. The SELDI-TOF mass spectrometry we used (pBluescript II) did not have the necessary mass accuracy to identify potential proteins. The 3- to 5-kDa cluster we identified in IAI contained several peaks and each peak could represent multiple proteins, including defensins. Heine et al1 described defensins in vaginal secretions by using enzyme-linked immunosorbent assay.

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