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December 15, 2004

Antidepressants and the Risk of Suicidal Behaviors

JAMA. 2004;292(23):2833-2834. doi:10.1001/jama.292.23.2833-a

To the Editor: Dr Jick and colleagues1 reported that the risk of suicidal behavior after initiating antidepressant treatment is similar among users of amitriptyline, fluoxetine, and paroxetine compared with the risk among users of dothiepin. This finding is relevant in countries where dothiepin is a reference antidepressant, such as the United Kingdom, but is less helpful where this agent has never been licensed, such as Italy and the United States.

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