To the Editor: Dr Jick and colleagues1 reported that the risk of suicidal behavior after
initiating antidepressant treatment is similar among users of amitriptyline,
fluoxetine, and paroxetine compared with the risk among users of dothiepin.
This finding is relevant in countries where dothiepin is a reference antidepressant,
such as the United Kingdom, but is less helpful where this agent has never
been licensed, such as Italy and the United States.
Barbui C. Antidepressants and the Risk of Suicidal Behaviors. JAMA. 2004;292(23):2833–2834. doi:10.1001/jama.292.23.2833-a