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December 15, 2004

Antidepressants and the Risk of Suicidal Behaviors—Reply

Author Affiliations

Letters Section Editor: Robert M. Golub, MD, Senior Editor.

JAMA. 2004;292(23):2833-2834. doi:10.1001/jama.292.23.2833-c

In Reply: Dr Barbui asks what the results of our study would have been if we had chosen amitriptyline rather than dothiepin as the comparator. Correcting for multiple comparisons and using amitriptyline as the reference exposure, the odds ratios (confidence intervals) for nonfatal suicidal behaviors among users of the other 3 antidepressants we studied are dothiepin, 1.21 (0.80-1.83); fluoxetine, 1.40 (0.92-2.13); and paroxetine, 1.55 (0.99-2.43). These are estimated 99.17% confidence intervals, which we believe is most appropriate in this post hoc analysis to maintain overall type I error less than 5% while allowing for all 6 pairwise comparisons among the 4 exposure groups. These results and their interpretation are consistent with those reported in our study.

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