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January 26, 2005

Predictors of Lack of Improvement After Thrombolytic Stroke Therapy—Reply

JAMA. 2005;293(4):421. doi:10.1001/jama.293.4.421-b

In Reply: Dr Pastewski and colleagues would like more information on patients treated with alteplase after 3 hours. In our study, no patient received alteplase less than 60 minutes before or 270 minutes after onset of symptoms. Of the 40 patients (18%) who received alteplase after 3 hours, 20 (50%) had a poor outcome (modified Rankin scale ≥3) at 90 days. The study was not powered to demonstrate a statistically significant difference in outcome at 90 days between patients that received alteplase within or outside the 3-hour window.

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