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February 16, 2005

Community-Acquired Pneumonia and Use of Gastric Acid–Suppressive Drugs—Reply

JAMA. 2005;293(7):795-796. doi:10.1001/jama.293.7.796-a

In Reply: Dr Sataloff’s concern about the choice of the control group in our study seems to assume that all patients taking proton pump inhibitors had gastroesophageal reflux disease. However, only 30% of our study population had endoscopically confirmed gastroesophageal reflux disease. If Dr Sataloff is correct that reflux is associated with pneumonia, we would have expected reflux esophagitis to have been more frequently present in patients with pneumonia than in the control group. This was not the case, as was shown in Table 2 of our article. We also note that an American Gastroenterological Association consensus panel concluded that causation has not been established for pulmonary extraesophageal manifestations of gastroesophageal reflux disease.1

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