In Reply: We were indeed surprised that bloodstream
infections with coagulase-negative staphylococci, often considered low-virulence
organisms, were associated with subsequent adverse outcomes in ELBW infants
and agree that these infants should be included in therapeutic trials. In
contrast, ELBW infants with culture-negative clinical infection represent
a spectrum of clinical disease ranging from relatively mild to very severe
illness; thus, adverse outcomes in this group are less surprising. We did
not collect information on pneumonia.
Stoll BJ, Hansen N, National Institute of Child Health and
Human Development Neonatal Research Network FT. Neurodevelopmental Impairment and Neonatal Infections—Reply. JAMA. 2005;293(8):932. doi:10.1001/jama.293.8.932-b
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