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February 23, 2005

Neurodevelopmental Impairment and Neonatal Infections—Reply

JAMA. 2005;293(8):932. doi:10.1001/jama.293.8.932-b

In Reply: We were indeed surprised that bloodstream infections with coagulase-negative staphylococci, often considered low-virulence organisms, were associated with subsequent adverse outcomes in ELBW infants and agree that these infants should be included in therapeutic trials. In contrast, ELBW infants with culture-negative clinical infection represent a spectrum of clinical disease ranging from relatively mild to very severe illness; thus, adverse outcomes in this group are less surprising. We did not collect information on pneumonia.