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March 16, 2005

Estrogen Plus Progestin and Risk of Venous Thrombosis

Author Affiliations

Letters Section Editor: Robert M. Golub, MD, Senior Editor.

JAMA. 2005;293(11):1322-1323. doi:10.1001/jama.293.11.1322-b

To The Editor: The study by Dr Cushman and colleagues1 is based on data from the WHI and details of the methods are reported in an earlier JAMA publication.2 The prior study notes that of the 8506 participants in the CEE + MPA group, 3444 (40.5%) were unblinded for control of vaginal bleeding. Further, CEE and/or MPA doses could have been altered for treatment of this condition, yet no published data from this trial have indicated the effect that this treatment had on the study outcomes. It seems inaccurate to label this a blinded controlled trial of placebo against CEE + MPA.

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