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April 6, 2005

Cardiovascular Outcomes and Antihypertensive Drug Treatment in Older Women

JAMA. 2005;293(13):1588-1589. doi:10.1001/jama.293.13.1588-b

To the Editor: The study by Dr Wassertheil-Smoller and colleagues1 investigated cardiovascular outcomes in older women using various combinations of diuretics, β-blockers, CCBs, and ACE inhibitors. However, it does not report results of the β-blocker plus ACE inhibitor or the β-blocker plus CCB combinations. The β-blocker plus ACE inhibitor combination has gained attention following the ALLHAT study, which reported higher rates of cardiovascular disease, heart failure, and stroke for patients receiving an ACE inhibitor (lisinopril)2. This combination was also found to be ineffective for control of blood pressure when β-blocker monotherapy had failed3.

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