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May 18, 2005

Perspectives on New Recommendations for Nonoccupational HIV Postexposure Prophylaxis

JAMA. 2005;293(19):2407-2409. doi:10.1001/jama.293.19.2407

In an important initial step for providing advice to US clinicians on this complex subject, the Centers for Disease Control and Prevention (CDC) recently released national guidelines for provision of human immunodeficiency virus (HIV) nonoccupational postexposure prophylaxis (HIV NPEP).1 In the guidelines, the CDC defines nonoccupational exposure as

any direct mucosal, percutaneous, or intravenous contact with potentially infectious body fluids that occurs outside perinatal or occupational situations (eg, health care, sanitation, public safety, or laboratory employment). Potentially infectious body fluids are blood, semen, vaginal secretions, rectal secretions, breast milk, or other body fluid that is contaminated with visible blood.

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