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The World in Medicine
May 18, 2005

Lumbar Disc Disease

JAMA. 2005;293(19):2333. doi:10.1001/jama.293.19.2333-d

Although lumbar disc disease has long been recognized as a primary cause of lower back pain and studies have pointed to a genetic component for its development, its etiology and pathogenesis are largely unknown. Now, researchers from Japan reported on May 1 in an online edition of Nature Genetics (http://npg.nature.com/) that they have identified a genetic variation associated with susceptibility to lumbar disc disease, a finding that could shed light on factors that contribute to disc degeneration.