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May 25, 2005

Detection of Bladder Cancer Using a Proteomic Assay

Author Affiliations

Letters Section Editor: Robert M. Golub, MD, Senior Editor.

JAMA. 2005;293(20):2466-2467. doi:10.1001/jama.293.20.2466-b

To the Editor: In their article on detection of bladder cancer using a proteomic assay,1 Dr Grossman and colleagues do not specify why the studied patients underwent cystoscopy. It is necessary to understand the study population to judge validity and generalizability. In particular, it would be important to know what percentage of the patients had symptoms or signs, how many had occupational exposure, and how many were screened solely because they were smokers. Given the absence of standard screening recommendations based on smoking status, if this were the basis for testing in some of these subjects I would want to know if it was because of current or past smoking, or whether it was based on amount smoked per day.