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Current recommendations for menopausal symptom management with hormone
therapy encourage prescription of the lowest effective dosage for the shortest
duration possible. However, few data exist regarding symptoms experienced
when hormone therapy is discontinued. Ockene and colleaguesArticle report
results of a survey completed by 8405 women (89.9% of those eligible) who
were still taking their study medication (combined conjugated equine estrogens
plus medroxyprogesterone acetate [CEE + MPA] or placebo) when the
Women’s Health Initiative trial was stopped. Among their findings were
that women formerly taking CEE + MPA reported more symptoms than
women formerly taking placebo and that the presence of symptoms at baseline
was associated with increased symptom reports after stopping either CEE + MPA
or placebo. In an editorial, Petitti Article discusses
symptoms of menopause, aging, and treatment options.
This Week in JAMA . JAMA. 2005;294(2):153. doi:https://doi.org/10.1001/jama.294.2.153
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