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August 10, 2011

Biomarkers for Detecting and Risk-Stratifying Chronic Kidney Disease

Author Affiliations

Author Affiliations: Department of Clinical Nursing, Fourth Military Medical University, Xi’an, China (cuiyan@fmmu.edu.cn).

JAMA. 2011;306(6):611-612. doi:10.1001/jama.2011.1111

To the Editor: Dr Peralta and colleagues1 reported that “adding cystatin C to creatinine and albuminuria for risk prediction can more accurately reclassify persons and can distinguish important prognostic differences, namely a 3-fold risk of death and 4-fold risk of end-stage renal disease.” However, they did not explain why they chose cystatin C as a biomarker for CKD diagnosis or assess the accuracy of applying it.