Letters Section Editor: Robert M. Golub,
MD, Senior Editor.
To the Editor: In their study of the long-term
outcomes following conservative management of localized prostate cancer, Dr
Albertsen and colleagues1 conclude that a Gleason
score of 2 to 4 is a very good prognostic sign. However, the Gleason score
is a highly subjective measure that is based on a pathologists’ perception
of tissue patterns. A much more objective prognostic measure is the DNA content
or ploidy of tumor cells.2,3
Koss LG. Localized Prostate Cancer and DNA Ploidy. JAMA. 2005;294(10):1207–1208. doi:10.1001/jama.294.10.1207-a
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