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September 14, 2005

Localized Prostate Cancer and DNA Ploidy

JAMA. 2005;294(10):1207-1208. doi:10.1001/jama.294.10.1207-a

To the Editor: In their study of the long-term outcomes following conservative management of localized prostate cancer, Dr Albertsen and colleagues1 conclude that a Gleason score of 2 to 4 is a very good prognostic sign. However, the Gleason score is a highly subjective measure that is based on a pathologists’ perception of tissue patterns. A much more objective prognostic measure is the DNA content or ploidy of tumor cells.2,3

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