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September 28, 2005

Clinical Factors and Recurrent Venous Thrombotic Events

JAMA. 2005;294(12):1489-1490. doi:10.1001/jama.294.12.1489-a

To the Editor: In their study of thrombophilia, Dr Christiansen and colleagues1 examine the comparative rates of thrombosis in patients with idiopathic and provoked clots, as well as the presence or absence of prothrombotic characteristics in these groups. When considering provoked thrombotic events, particularly in those patients who are in the hospital and are at high risk for clotting, the use of prophylactic measures other than oral anticoagulants (such as subcutaneous heparin or intermittent pneumatic compression devices) will notably influence the outcome of interest. While not mentioned in the protocol, it would be helpful to know if the authors obtained this information and considered this potential bias.

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