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October 5, 2005

Nonalcoholic Fatty Liver and Insulin Resistance Among Petrochemical Workers

Author Affiliations

Letters Section Editor: Robert M. Golub, MD, Senior Editor.

JAMA. 2005;294(13):1615-1620. doi:10.1001/jama.294.13.1618-b

To the Editor: Insulin resistance (IR) and features of the metabolic syndrome are often associated with nonalcoholic fatty liver disease (NAFLD). Insulin resistance has been considered to be essential for the development of NAFLD.1 However, multiple mechanisms are involved in the pathogenesis of NAFLD.2 We previously described a form of NAFLD among petrochemical workers, affecting predominantly younger men, causing mild fibrosis and cholestasis.3,4 In the current study we evaluated the relationship of IR to NAFLD among petrochemical workers.