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Clinical Crossroads
Clinician's Corner
November 2, 2005

A 21-Year-Old Woman With Atypical Squamous Cells of Undetermined Significance

JAMA. 2005;294(17):2210-2218. doi:10.1001/jama.294.17.2210

DR REYNOLDS: Ms G is a 21-year-old woman with a history of abnormal Papanicolaou (Pap) tests.

Ms G first became sexually active at age 19. That year, she had her first gynecologic examination when she visited a doctor to ask for an oral contraceptive pill prescription. Her examination and cytology test were normal. She had annual Pap screening until age 21, when her cytology test (conventional) showed atypical squamous cells of undetermined significance (ASC-US). Her clinician, a nurse practitioner at student health, recommended a repeat cytology test in 6 months. Her repeat test again showed ASC-US, and she was referred to a gynecologist who performed a colposcopy.

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