Three decades ago, the primary results of the Multiple Risk Factor Intervention Trial (MRFIT) were published in JAMA; that trial attempted to demonstrate benefits from lowering cholesterol (with diet) and managing other known risk factors for reducing cardiovascular morbidity and mortality.1 Since then, multiple trials have shown cardiovascular benefit from lowering cholesterol, especially low-density lipoprotein cholesterol (LDL-C).2,3 However, as of 1993, no trial had demonstrated a clear reduction in total mortality and, thus, debate still raged as to whether it was beneficial to reduce cholesterol.3
Cannon CP. The IDEAL CholesterolLower Is Better. JAMA. 2005;294(19):2492–2494. doi:10.1001/jama.294.19.2492
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