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December 14, 2005

Risk Factors for Cardiovascular Disease in Women—Reply

JAMA. 2005;294(22):2843-2844. doi:10.1001/jama.294.22.2844-a

In Reply: Mr Vos and Dr Rose express concern that our primary end point included revascularization procedures. When these are eliminated from the analysis, among those persons in the top quintile of apolipoprotein B100, the relative risk compared with the lowest quintile is 1.62 (95% confidence [CI], 1.05-2.52); non–HDL cholesterol, 1.91 (95% CI, 1.22-2.99); ratio of total cholesterol to HDL cholesterol, 2.84 (95% CI, 1.76-4.60); and high-sensitivity C-reactive protein, 3.14 (95% CI, 1.80-5.47). Thus, as reported for our primary end point, non–HDL cholesterol and the ratio of total cholesterol to HDL cholesterol were superior to apolipoprotein B100 for the end point of “hard” cardiovascular events, and high-sensitivity C-reactive protein remained the single strongest predictor of risk. The total number of deaths in our study is insufficient to robustly address mortality as a single end point.

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