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December 28, 2005

Continuing Anticoagulation Following Venous Thromboembolism—Reply

JAMA. 2005;294(24):3088-3089. doi:10.1001/jama.294.24.3088-b

In Reply: We agree with Drs Krakow and Ortel that generalizability is important. Whether any study, be it a randomized controlled trial (RCT) or an epidemiologic study, can be applied to a given patient is a question of external validity. We recognize that RCT methodology limits external validity. However, the blanket statement that “the appropriate incidence rate ratio for bleeding is not one pooled from clinical trials, but from epidemiologic studies” is too broad.

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