[Skip to Content]
[Skip to Content Landing]
Citations 0
December 28, 2005

Long-term Use of Aspirin and Risk of Colorectal Cancer

JAMA. 2005;294(24):3090-3091. doi:10.1001/jama.294.24.3090-b

To the Editor: In their study on aspirin, nonsteroidal anti-inflammatory drugs, and the risk of colorectal cancer, Dr Chan and colleagues1 conclude that regular, long-term aspirin use reduces risk of colorectal cancer. Although the study shows that long-term users of aspirin have a lower incidence of colorectal cancer, aspirin itself may not be the cause of this observation. The situation may be analogous to earlier results of the Nurses' Health Study,2 in which the apparent reduced cardiac and mortality risks from estrogen use may have been artifacts of confounding or selection bias, based on results of a subsequent randomized controlled trial.3

First Page Preview View Large
First page PDF preview
First page PDF preview