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January 4, 2006

Apolipoprotein E and Progression of Chronic Kidney Disease

Author Affiliations

Letters Section Editor: Robert M. Golub, MD, Senior Editor.

JAMA. 2006;295(1):35-36. doi:10.1001/jama.295.1.35-a

To the Editor: Dr Hsu and colleagues1 concluded that apolipoprotein E (APOE) gene variation predicted chronic kidney disease progression, independent of diabetes, race, lipid, and nonlipid factors. The authors state that the APOE association with chronic kidney disease progression was not explained by established kidney disease risk factors including diabetes and hypertension.