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January 4, 2006

Apolipoprotein E and Progression of Chronic Kidney Disease—Reply

Author Affiliations

Letters Section Editor: Robert M. Golub, MD, Senior Editor.

JAMA. 2006;295(1):35-36. doi:10.1001/jama.295.1.35-b

In Reply: Dr Kida suggests that the use of ACE inhibitors or ARBs may confound the association between APOE genotype and chronic kidney disease progression. Use of antihypertensive medication had been adjusted for in our multivariate Cox models and did not modify the association between APOE and chronic kidney disease progression, which is the expected result given that antihypertensive medication use should not be associated with APOE genotype.