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January 25, 2012

BRCA1 and BRCA2 Mutations in Ovarian Cancer

Author Affiliations

Author Affiliations: Department of Obstetrics & Gynecology, University of Bochum School of Medicine, Herne, Germany (Clemens.tempfer@marienhospital-herne.de).

JAMA. 2012;307(4):359-361. doi:10.1001/jama.2012.8

To the Editor: Dr Yang and colleagues found significantly better progression-free survival rates in women with ovarian cancer and BRCA2 mutations compared with BRCA1 mutations or wild-type BRCA.1 In addition, they reported that BRCA2 mutations were associated with a 100% primary chemotherapy sensitivity rate compared with 82% for BRCA wild-type and 80% for BRCA1- mutated cases, suggesting an improved primary chemotherapy response in women with a BRCA2 mutation. We would like to suggest 2 alternative explanations for the observed differences in outcomes.