[Skip to Content]
[Skip to Content Landing]
February 1, 2006

Atypical Antipsychotic Drugs, Dementia, and Risk of Death

Author Affiliations

Letters Section Editor: Robert M. Golub, MD, Senior Editor.

JAMA. 2006;295(5):495-497. doi:10.1001/jama.295.5.495-b

To the Editor: In their meta-analysis, Dr Schneider and colleagues1 present evidence of a small but significant increase in the risk of death when antipsychotic drugs are used to treat neuropsychiatric symptoms in older adults with dementia. This risk develops quickly and is consistent across trials evaluating different antipsychotic agents. Antipsychotic drugs are used in a variety of treatment settings. For several reasons, the results of this meta-analysis may have implications for the safety of antipsychotic use in the setting of delirium treatment.