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Book and Media Reviews
February 22, 2006


Author Affiliations

Book and Media Reviews Section Editor: Harriet S. Meyer, MD, Contributing Editor, JAMA.

JAMA. 2006;295(8):942-943. doi:10.1001/jama.295.8.942

In their new book, Evan Derenzo and Joel Moss don't mince words—their point is clear from the outset:

The ethical aspects of a clinical trial cannot be separated from the scientific objectives. Segregation of ethical issues from the full range of study design components demonstrates a flaw in understanding the fundamental nature of research involving human subjects.

Over the years, many have made this point, but few have taken it so seriously or addressed it more pragmatically than these authors, and their delivery is effective. This pairing of a distinguished ethicist with an accomplished and respected physician-scientist, both with roots at the National Institutes of Health, makes for an informative, authoritative, and very useful presentation.

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