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March 1, 2006

Urine Telomerase and Bladder Cancer Detection

Author Affiliations

Letters Section Editor: Robert M. Golub, MD, Senior Editor.

JAMA. 2006;295(9):998-999. doi:10.1001/jama.295.9.998-a

To the Editor: Dr Sanchini and colleagues1 studied the relevance of urine telomerase in the diagnosis of bladder cancer. The authors expressed telomerase activity in arbitrary enzymatic units (AEU), which added the potential benefit of a quantitative cutoff or baseline value to the telomeric repeat amplification protocol (TRAP) assay. The quantification of telomerase activity, expressed as AEU, may allow for a more rigorous interpretation of the results and facilitate the clinical use of telomerase activity as a biomarker for cancer.