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March 22/29, 2006

Shyness, Social Anxiety, and Impaired Self-esteem in Turner Syndrome and Premature Ovarian Failure

JAMA. 2006;295(12):1373-1378. doi:10.1001/jama.295.12.1374

To the Editor: Shyness and social anxiety are reported in women with Turner syndrome (TS).1 Possible contributors include physical stigmata, such as short stature and neck-webbing, chromosomally-based deficits in social cognition, and premature ovarian failure with infertility. To investigate the potential role of premature ovarian failure and infertility, we compared measures of psychosocial distress in women with TS, women with spontaneous karyotypically normal premature ovarian failure (POF), and healthy controls.