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April 12, 2006

Supplemental Oxygen and Risk of Surgical Wound Infection

Author Affiliations

Letters Section Editor: Robert M. Golub, MD, Senior Editor.

JAMA. 2006;295(14):1641-1643. doi:10.1001/jama.295.14.1641-b

To the Editor: Dr Belda and colleagues1 reported that the administration of 80% FIO2 during and for 6 hours after surgery significantly reduced postoperative wound infection risk in patients undergoing major colorectal surgery. There were no reported adverse effects of high inspired oxygen concentrations, and the authors concluded that supplemental oxygen appeared to confer only few risks to the patient. However, there is evidence that increased oxygen concentrations may be harmful for some patients, especially for those with preexisting pulmonary disease.2