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May 10, 2006

Caffeine and Incident Hypertension in Women

Author Affiliations

Letters Section Editor: Robert M. Golub, MD, Senior Editor.

JAMA. 2006;295(18):2135-2137. doi:10.1001/jama.295.18.2135-a

To the Editor: Dr Winkelmayer and colleagues1 found an inverse U-shaped relationship between habitual caffeine consumption and incident hypertension in a prospective cohort study of US women followed up for 12 years in the Nurses' Health Studies. However, when examining classes of caffeinated beverages, coffee consumption was not linked to an increased risk of hypertension. In contrast, cola beverage consumption was associated with an increased risk, independent of whether it was sugared or diet cola. The authors speculated that the substance responsible for the increased risk of hypertension in the cola drinks is a compound other than caffeine.